Of course it can, it comes with a non-xml version that you could use. But as seeing how the XML Spawner system is so much more then just the spawners, I believe all shard owners should have the system in. It truly can do way more then you could imagine.
You can install the XML Spawner system and still run Nerun's distro. I converted all of the default RunUO spawns into xml spawns with the built in commands, so I don't have any Premium Spawners anywhere on the map (although they are still installed on the shard, just never used.) I just think the xml spawners are so more feature packed, and allow you to control...any aspect of spawning something. You could create a custom mob, give it a custom item to drop, make it part of a quest, ect. All with just one of these spawners. Or just spawn a dog in town, lol. The point is, it's just a spawner. XML Spawner is a pretty robust system, that supports way more then just spawners. It supports xml attachments, which is what this package uses if you get the xml version of it.
It lets the Custom Vendors take points from xml attachments such as the pvp one. So you could sell items for pvp points. Or any other property from an xml attachment, which allow you to do tons without making distro edits to rather large files like playermobile or basecreature.
Even if you grab the non xml version of this, I still suggest you research the XML Spawner system a little more before deciding not to use it. =P